Forsythoside B

Forsythoside B is phenylpropanoid glycoside that has been found in M. alysson and has diverse biological activities. It scavenges PTIO (Cay-14982), ABTS (Cay-27317), O2-, and 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 µM, respectively). Forsythoside B (10-100 µg/ml) reduces hydrogen peroxide-induced cytotoxicity in bone marrow-derived mesenchymal stem cells (bmMSCs). It inhibits 2-aminoethoxydiphenyl borate-induced activation of transient receptor potential vanilloid 3 (TRPV3, IC50 = 6.7 µM in HEK293 cells expressing the human receptor) and reduces carvacrol-induced scratching behavior in mice. Forsythoside B (40 mg/kg) reduces serum levels of TNF-alpha, IL-6, IL-10, endotoxin, and triggering receptor expressed on myeloid cells 1 (TREM-1) and increases survival in a rat model of cecal ligation and puncture-induced sepsis. It also reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion.Formal Name: 2-(3,4-dihydroxyphenyl)ethyl O-D-apio-beta-D-furanosyl-(1->6)-O-[6-deoxy-alpha-L-mannopyranosyl-(1->3)]-beta-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]. CAS Number: 81525-13-5. Molecular Formula: C34H44O19. Formula Weight: 756.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 333 nm. SMILES: OC(C=C1)=C(O)C=C1CCO[C@@H]2O[C@H](CO[C@H]3[C@H](O)[C@](CO)(O)CO3)[C@@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@H]2O. InChi Code: InChI=1S/C34H44O19/c1-15-24(41)25(42)26(43)32(50-15)53-29-27(44)31(47-9-8-17-3-6-19(37)21(39)11-17)51-22(12-48-33-30(45)34(46,13-35)14-49-33)28(29)52-23(40)7-4-16-2-5-18(36)20(38)10-16/h2-7,10-11,15,22,24-33,35-39,41-46H,8-9,12-14H2,1H3/b7-4+/t15-,22+,24-,25+,26+,27+,28+,29+,30-,31+,32-,33+,34+/m0/s1. InChi Key: JMBINOWGIHWPJI-UNSOMVRXSA-N. Origin: Plant/Callicarpa kwangtungensis.