Forskolin

Forskolin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11018-1 1 mg -

6 - 10 business days*

25.00€
Cay11018-5 5 mg -

6 - 10 business days*

57.00€
Cay11018-10 10 mg -

6 - 10 business days*

75.00€
Cay11018-50 50 mg -

6 - 10 business days*

150.00€
 
Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of... more
Product information "Forskolin"
Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 µM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Formal Name: 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-naphtho[2,1-b]pyran-1-one. CAS Number: 66575-29-9. Synonyms: Coleonol, HL 362, L 75-1362B, NSC 357088, NSC 375489. Molecular Formula: C22H34O7. Formula Weight: 410.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 15 mg/ml. SMILES: C[C@@](C1)(C=C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@@]2(O)C1=O. InChi Code: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1. InChi Key: OHCQJHSOBUTRHG-KGGHGJDLSA-N.
Keywords: Coleonol, HL 362, L 75-1362B, NSC 357088, NSC 375489, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-naphtho[2,1-b]pyran-1-one
Supplier: Cayman Chemical
Supplier-Nr: 11018

Properties

Application: Adenylate cyclase activator
MW: 410.5 D
Formula: C22H34O7
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 66575-29-9| Matching products
KEGG ID : K08042 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H312
P Phrases: P280, P302+352, P312, P321, P361+364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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