Forodesine

Description: Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas. Target: Apoptosis. Smiles: OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O. References: Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010,2010:131895.