Flupirtine-d4 (hydrochloride)

Flupirtine-d4 is intended for use as an internal standard for the quantification of flupirtine (Cay-16674) by GC- or LC-MS. Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ). It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice. Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine. Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.Formal Name: N-[2-amino-6-[[(4-fluorophenyl-d4)methyl]amino]-3-pyridinyl]-carbamic acid, ethyl ester, monohydrochloride. CAS Number: 1324717-75-0. Molecular Formula: C15H13D4FN4O2 . HCl. Formula Weight: 344.8. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Acetone: slightly soluble, Methanol: slightly soluble, Water: slightly soluble. SMILES: FC(C([2H])=C1[2H])=C([2H])C([2H])=C1CNC2=CC=C(NC(OCC)=O)C(N)=N2.Cl. InChi Code: InChI=1S/C15H17FN4O2.ClH/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10,/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20),1H/i3D,4D,5D,6D,. InChi Key: WBAZQELGBFQHPE-HGSONKNXSA-N.