Flunixin (meglumine)

Flunixin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 (IC50s = 3.24 and 0.55 µM, respectively). It inhibits carrageenan-induced prostaglandin E2 (PGE2, Cay-14010) and thromboxane B2 (TXB2, Cay-19030) production in sheep exudate and serum, respectively, when administered at a dose of 1.1 mg/kg. Flunixin (1.1 mg/I/kg) has anti-inflammatory, analgesic, and antipyretic activity in horses. Formulations containing flunixin have been used in the veterinary treatment of pain and fever in livestock.Formal Name: 1-deoxy-1-(methylamino)-D-glucitol, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate. CAS Number: 42461-84-7. Synonyms: NIH 10250. Molecular Formula: C14H11F3N2O2 . C7H17NO5. Formula Weight: 491.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 279 nm. SMILES: CC1=C(NC2=NC=CC=C2C(O)=O)C=CC=C1C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O. InChi Code: InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12,1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21),4-13H,2-3H2,1H3/t,4-,5+,6+,7+/m.0/s1. InChi Key: MGCCHNLNRBULBU-WZTVWXICSA-N.