Flavoxate (hydrochloride)

Flavoxate is an inhibitor of L-type calcium channels and an antimuscarinic agent. It induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces contractions induced by the acetylcholine receptor agonist carbachol (carbamoylcholine, Cay-14486) or calcium in isolated rat detrusor strips. Microinjection of flavoxate (0.68 µg/animal) into the oral pontine reticular nucleus inhibits reflex micturition in decerebrated cats, and intravenous or intracerebroventricular administration reduces isovolumetric rhythmic bladder contractions in rats. Formulations containing flavoxate have previously been used in the treatment of frequent or urgent urination, increased nocturnal urination, bladder pain, and urinary incontinence.Formal Name: 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester, monohydrochloride. CAS Number: 3717-88-2. Synonyms: NSC 114649, Rec 7/0040. Molecular Formula: C24H25NO4 . HCl. Formula Weight: 427.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 241, 289, 316 nm. SMILES: CC1=C(C2=CC=CC=C2)OC3=C(C(OCCN4CCCCC4)=O)C=CC=C3C1=O.Cl. InChi Code: InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25,/h2,4-5,8-12H,3,6-7,13-16H2,1H3,1H. InChi Key: XOEVKNFZUQEERE-UHFFFAOYSA-N.