FerroLOXIN-1

FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex. It selectively inhibits the peroxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (Cay-25871) by the 15-LO-2/PEBP1 complex over 15-LO-2 alone in cell-free assays when used at a concentration of 0.25 µM. FerroLOXIN-1 inhibits RSL3-induced ferroptosis in primary human bronchial epithelial cells (IC50 = 84 nM). It increases survival in a mouse model of total body irradiation when administered at a dose of 25 mg/kg.Formal Name: 1-(3-fluorophenyl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-phenyl-1H-imidazol-2-amine. CAS Number: 2773428-48-9. Molecular Formula: C23H16F5N3. Formula Weight: 429.4. Purity: >90%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Chloroform: Soluble. SMILES: FC1=CC=CC(N2C(NCC(C=C3)=CC(F)=C3C(F)(F)F)=NC(C4=CC=CC=C4)=C2)=C1. InChi Code: InChI=1S/C23H16F5N3/c24-17-7-4-8-18(12-17)31-14-21(16-5-2-1-3-6-16)30-22(31)29-13-15-9-10-19(20(25)11-15)23(26,27)28/h1-12,14H,13H2,(H,29,30). InChi Key: TZTVXYFOBQIIBL-UHFFFAOYSA-N.