Febrifugine

Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.Formal Name: 3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone. CAS Number: 24159-07-7. Synonyms: (+)-Febrifugine, NSC 315535. Molecular Formula: C16H19N3O3. Formula Weight: 301.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.5 mg/ml, DMSO: 3.0 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 2.5 mg/ml. lambdamax: 225, 266, 302, 314 nm. SMILES: O=C1N(CC(C[C@H]2NCCC[C@@H]2O)=O)C=NC3=CC=CC=C31. InChi Code: InChI=1S/C16H19N3O3/c20-11(8-14-15(21)6-3-7-17-14)9-19-10-18-13-5-2-1-4-12(13)16(19)22/h1-2,4-5,10,14-15,17,21H,3,6-9H2/t14-,15+/m1/s1. InChi Key: FWVHWDSCPKXMDB-CABCVRRESA-N. Origin: Plant/Dichroa febrifuga Lour.