Famciclovir

Famciclovir is an orally bioavailable prodrug form of the antiviral guanosine analog penciclovir (Cay-22918). Famciclovir is rapidly deacetylated and oxidized in vivo to form penciclovir, which is active against clinical isolates of herpes simplex virus 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) in a plaque reduction assay with IC50 values of 1.6, 6, and 12 µM, respectively. Both famciclovir and the product of its deacetylation, 6-deoxypenciclovir, are oxidized in vitro by human, guinea pig, and rat liver aldehyde oxidase, with 6-deoxypenciclovir being converted to penciclovir. Peak plasma concentrations of penciclovir (mean 3.5 µg/ml) are reached 0.5 hours after oral administration of famciclovir (40 mg/kg) in rats. Famciclovir (25 mg/kg) has a longer half-life in dogs, with peak concentrations of penciclovir (mean 4.4 µg/ml) in plasma occurring after 3 hours.Formal Name: 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol, 1,3-diacetate. CAS Number: 104227-87-4. Synonyms: BRL 42810. Molecular Formula: C14H19N5O4. Formula Weight: 321.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 223, 311 nm. SMILES: NC1=NC(N(CCC(COC(C)=O)COC(C)=O)C=N2)=C2C=N1. InChi Code: InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18). InChi Key: GGXKWVWZWMLJEH-UHFFFAOYSA-N.