EZ Cap(TM) Cas9 mRNA (mo5U)

EZ Cap(TM) Cas9 mRNA encodes for Cas9, a DNA endonuclease that induces breaks in DNA sequences complementary to single-guide RNA (sgRNA) strands and is commonly used for genome editing. It is capped using a co-transcriptional capping method, resulting in the naturally occurring Cap 1 structure with high capping efficiency. EZ Cap(TM) Cas9 mRNA is also polyadenylated and modified with 5-methyoxy-UTP (mo5U) to reduce the host cell immune response and enhance mRNA stability. Encapsulation of EZ Cap(TM) Cas9 mRNA (mo5U) in lipid nanoparticles (LNPs) can be used for mRNA delivery and expression of Cas9 in vitro or in vivo.Synonyms: EZ CapTM Cas9 mRNA (5-moUTP). Formulation: (Request formulation change), 1 mM Sodium citrate, pH 6.4.