Eupatorin

Eupatorin is a flavonoid that has been found in L. camara and has diverse biological activities. It inhibits the growth of HeLa, MK-1, and B16/F10 tumor cells (GI50s = 15, 58, and 44 µM, respectively). Eupatorin is active against T. cruzi epimastigotes and trypomastigotes (IC50s = 0.2 and 61.8 µg/ml, respectively) without inducing cytotoxicity in Vero cells (IC50 = >500 µg/ml). It induces vasorelaxation in isolated rat thoracic aortic rings precontracted with phenylephrine (pD2 = 6.66). Eupatorin (10 and 100 µM) reduces nuclear translocation of NF-kappaB and STAT1alpha in J774 murine macrophages and reduces paw edema in a mouse model of carrageenan-induced paw inflammation when administered at a dose of 50 mg/kg.Formal Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one. CAS Number: 855-96-9. Synonyms: NSC 106402. Molecular Formula: C18H16O7. Formula Weight: 344.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 216, 242, 276, 343 nm. SMILES: O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC(O)=C(OC)C=C3)=C1. InChi Code: InChI=1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3. InChi Key: KLAOKWJLUQKWIF-UHFFFAOYSA-N. Origin: Plant/Orthosiphon aristatus.