ESI-09

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). ESI-09 is an inhibitor of Epac1 and Epac2 with IC50 values of 3.2 and 1.4 µM, respectively. It shows no activity against PKA at concentrations as high as 25 µM. ESI-09 has been shown to block Akt phosphorylation and insulin secretion in pancreatic beta cells, as well as to block the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.Formal Name: alpha-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile. CAS Number: 263707-16-0. Molecular Formula: C16H15ClN4O2. Formula Weight: 330.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 252, 367 nm. SMILES: ClC1=CC=CC(N/N=C(C#N)/C(C2=NOC(C(C)(C)C)=C2)=O)=C1. InChi Code: InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+. InChi Key: DXEATJQGQHDURZ-DEDYPNTBSA-N.