Esculin (hydrate)

Esculin is a coumarin that has been found in A. hippocastanum and has antioxidant and anti-inflammatory activities. It reduces the size of gastric ulcers and decreases increases in the levels of malondialdehyde (MDA) and the activity of myeloperoxidase (MPO) and catalase in a mouse model of ethanol-induced ulcers when used at a dose of 25 mg/kg. Esculin (20 mg/kg) decreases LPS-induced increases in the levels of TLR4, MyD88, IRAK4, and phosphorylated NF-?B in the lung, as well as levels of IL-1beta, IL-6, and TNF-alpha in the bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.Formal Name: 6-(beta-D-glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one, hydrate. Synonyms: Aesculin, Enallachrome. Molecular Formula: C15H16O9 . XH2O. Formula Weight: 340.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 225, 250, 335 nm. SMILES: O=C1C=CC2=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C(O)C=C2O1.O. InChi Code: InChI=1S/C15H16O9.H2O/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17,/h1-4,10,12-17,19-21H,5H2,1H2/t10-,12-,13+,14-,15-,/m1./s1. InChi Key: CQYPGSKIFJFVDQ-QWFKVUSTSA-N.