Epifriedelanol

Epifriedelanol is a triterpene that has been found in U. davidiana root bark and has anticancer and senescence modifying activities. It increases levels of P-glycoprotein (P-gp) and multidrug resistance protein 2 (MDR2) and enhances doxorubicin-induced cytotoxicity in doxorubicin-resistant K562/ADM cells when used at concentrations ranging from 5 to 20 µM. It also inhibits doxorubicin-induced senescence in isolated human dermal fibroblasts (HDFs), as well as replicative senescence in HDFs and human umbilical vein endothelial cells (HUVECs).Formal Name: (3beta,4beta,5beta,8alpha,9beta,10alpha,13alpha,14beta)-5,9,13-trimethyl-4,25,26-trinoroleanan-3-ol. CAS Number: 16844-71-6. Synonyms: Friedelan-3beta-ol, beta-Friedelinol, epi-Friedelanol, Longan Triterpane A. Molecular Formula: C30H52O. Formula Weight: 428.7. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, DMF: Slightly soluble, DMSO: Slightly soluble. SMILES: C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CCC(C)(C3)C)C)(CC[C@@]4([C@]2([H])CC[C@]5([C@@]4([H])CC[C@@H]([C@@H]5C)O)C)C)C. InChi Code: InChI=1S/C30H52O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20-24,31H,9-19H2,1-8H3/t20-,21-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1. InChi Key: XCDQFROEGGNAER-PFOIMGGJSA-N. Origin: Plant/Aster tataricus L. f..