ELOVL6-IN-4

Description: ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1]. Smiles: C(NC1=CC=C(C(F)(F)F)C=C1)(=O)N2[C@]3(C[C@H](S(=O)(=O)C4=CC=CC=N4)C[C@@]2(CC3)[H])[H]