Elobixibat hydrate

Elobixibat is a selective inhibitor of the ileal bile acid transporter (IBAT, also known as ASBT/SLC10A2), used primarily in research on cholesterol metabolism, bile acid regulation, and gastrointestinal motility disorders. By blocking bile acid reabsorption in the terminal ileum, elobixibat increases bile acid flow into the colon, which stimulates fluid secretion and accelerates colonic transit. Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colonic motility and has the potential to treat metabolic syndrome. It has been used in studies on chronic idiopathic constipation (CIC), nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia. Elobixibat is a valuable tool for studying enterohepatic circulation, FXR signaling and gut-liver axis interactions.