EGTA

EGTA is an aminopolycarboxylic acid chelating agent. It is selective for calcium over magnesium with Kapp values for calcium ranging from 6.93 to 10.7 x 105 M-1 in various buffers at pH 6.8 and 20°C. EGTA (5 mM) inhibits apoptosis induced by the sarcoplasmic/endoplasmic Ca2+-ATPase (SERCA) inhibitor thapsigargin (Cay-10522) in isolated rat thymocytes. It has been used as an irrigation agent to remove the smear layer from the pulp canal wall on extracted human teeth. Intranasal administration of EGTA enhances adenovirus-mediated gene transfer of LacZ to the trachea and main bronchi in mice by 8-fold.Formal Name: 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid. CAS Number: 67-42-5. Synonyms: Egtazic Acid, Ethylene Glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic Acid, Ethylene Glycol Tetraacetic Acid, GEDTA, NSC 615010. Molecular Formula: C14H24N2O10. Formula Weight: 380.4. Formulation: (Request formulation change), A solid. Solubility: 1 M NaOH: soluble, PBS (pH 7.2): slightly soluble. SMILES: O=C(CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O)O. InChi Code: InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24). InChi Key: DEFVIWRASFVYLL-UHFFFAOYSA-N.