Efipladib

Description: Efipladib is a phospholipase inhibitor. Efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid. Target: Others. Smiles: C(N1C=2C(C(CCCC3=CC=C(C(O)=O)C=C3)=C1CCNS(CC4=CC(Cl)=C(Cl)C=C4)(=O)=O)=CC(Cl)=CC2)(C5=CC=CC=C5)C6=CC=CC=C6. References: Nickerson-Nutter CL, Goodwin D, Shen MW, Damphousse C, Duan W, Samad TA, McKew JC, Lee KL, Zaleska MM, Mollova N, Clark JD. The cPLA2alpha inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid. Neuropharmacology. 2011 Mar,60(4):633-41. doi: 10.1016/j.neuropharm.2010.11.025. PubMed PMID: 21146550.