Echinosporin

Echinosporin is a bacterial metabolite originally isolated from Streptomyces echinosporus that has antibacterial and anticancer activities. It is active against P. vulgaris, S. typhosa, S. sonnei, E. coli, and B. subtilis (MICs = 100, 100, 100, 200, and 400 µg/ml, respectively). Echinosporin induces cell cycle arrest at the G2/M phase and apoptosis in, as well as inhibits proliferation of, HCT-15 human colorectal cancer cells (IC50s = 1.7, 1.75, and 247 µM, respectively). It inhibits tumor growth in murine P388 leukemia and Meth 1 fibrosarcoma models when administered at doses ranging from 10 to 80 mg/kg.Formal Name: (1S,4aS,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-8-oxo-1,5-(epoxymethano)cyclopenta[c]pyran-3-carboxamide. CAS Number: 79127-35-8. Synonyms: NSC 357683, XK-213. Molecular Formula: C10H9NO5. Formula Weight: 223.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, Methanol: soluble, Water: soluble. SMILES: O[C@@]12[C@]3([H])[C@@](C=C2)([H])[C@H](OC1=O)OC(C(N)=O)=C3. InChi Code: InChI=1S/C10H9NO5/c11-7(12)6-3-5-4-1-2-10(5,14)9(13)16-8(4)15-6/h1-5,8,14H,(H2,11,12)/t4-,5-,8-,10-/m0/s1. InChi Key: OXSZHYWOGQJUST-PDXIVQBHSA-N. Origin: Bacterium/Streptomyces sp..