E4CPG

E4CPG is an antagonist of metabotropic glutamate receptor 1 (mGluR1) and mGluR2. It is selective for mGluR1 and mGluR2 over mGluR6 at 1 mM. E4CPG (1 mM) inhibits L-glutamate-induced increases in inositol phosphate (InsP) levels in CHO cells expressing mGluR1 and prevents forskolin-induced decreases in cAMP levels in CHO cells expressing mGluR2. In vivo, intraplantar administration of E4CPG (1-10 nmol/paw) reduces glutamate-induced paw licking in a mouse model of nociceptive pain.Formal Name: alpha-amino-4-carboxy-alpha-ethyl-benzeneacetic acid. CAS Number: 170846-89-6. Synonyms: (R,S)-alpha-Ethyl-4-carboxyphenylglycine. Molecular Formula: C11H13NO4. Formula Weight: 223.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: insol, DMSO: insol, Ethanol: insol, PBS (pH 7.2): 100 µg/ml. lambdamax: 233 nm. SMILES: O=C(C1=CC=C(C(C(O)=O)(CC)N)C=C1)O. InChi Code: InChI=1S/C11H13NO4/c1-2-11(12,10(15)16)8-5-3-7(4-6-8)9(13)14/h3-6H,2,12H2,1H3,(H,13,14)(H,15,16). InChi Key: AIEFWRHRHFRLFT-UHFFFAOYSA-N.