(E/Z)-GO289

Description: (E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity. Target: Casein Kinase. Smiles: COc1cc(\C=N\n2c(SC)nnc2-c2ccccc2)c(Br)cc1O. References: Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019,5(1):eaau9060. Published 2019 Jan 23.