(E/Z)-Ajoene

(E/Z)-Ajoene is a disulfide that has been found in A. sativum and has antitumor and antiplatelet activities. It is cytotoxic to a variety of cancer cells, including B16-BL6 murine melanoma, and human HT-29 colon adenocarcinoma, MDA-MB-231 mammary, and PANC-1 pancreatic adenocarcinoma cells (IC50s = 18, 19, 7, and 38 µM, respectively). (E/Z)-Ajoene (25 mg/kg) reduces tumor growth and decreases the number of lung metastases in B16-BL6 murine models of melanoma. It also prevents thrombus formation in heparinized animals in a porcine model of severe vascular damage induced by intimal stripping and tunica media exposure when administered at a dose of 25 mg/kg.Formal Name: 2-propen-1-yl [3-(2-propen-1-ylsulfinyl)-1-propen-1-yl] disulfide. CAS Number: 92285-01-3. Molecular Formula: C9H14OS3. Formula Weight: 234.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethyl acetate. Solubility: Ethyl Acetate: 100 mg/ml. SMILES: C=CCS(C/C=C/SSCC=C)=O. InChi Code: InChI=1S/C9H14OS3/c1-3-6-11-12-7-5-9-13(10)8-4-2/h3-5,7H,1-2,6,8-9H2/b7-5+. InChi Key: IXELFRRANAOWSF-FNORWQNLSA-N. Origin: Synthetic.