Dynole 34-2

Dynole 34-2 is an inhibitor of dynamin (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively). It induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells when used at a concentration of 10 µM. Dynole 34-2 inhibits the proliferation of several cancer cell lines (GI50s = 5.8-15 µM).Formal Name: 2-cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide. CAS Number: 1128165-88-7. Molecular Formula: C25H36N4O. Formula Weight: 408.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100mM, Ethanol: 50mM. lambdamax: 222, 274, 381 nm. SMILES: N#CC(C(NCCCCCCCC)=O)=CC1=CN(CCCN(C)C)C2=C1C=CC=C2. InChi Code: InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30). InChi Key: MYIMRONQBLZJFI-UHFFFAOYSA-N.