DTPA

DTPA is a cell-impermeable metal chelating agent. It chelates copper, iron, zinc, and manganese, as well as calcium, magnesium, and plutonium. DTPA has been used as a metal chelating agent in the study of ferroptosis. It reduces the skeletal plutonium burden and incidence of bone tumors, as well as increases survival in a mouse model of intravenous plutonium exposure when administered at a dose of 500 mg/kg. Formulations containing DTPA conjugated to radioactive compounds have been used as diagnostic agents for brain imaging, renal visualization, and lung imaging.Formal Name: N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-glycine. CAS Number: 67-43-6. Synonyms: Diethylenetriaminepentaacetic Acid, NSC 7340, Pentetic Acid. Molecular Formula: C14H23N3O10. Formula Weight: 393.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Slightly soluble, Methanol: Slightly soluble, PBS (pH 7.2): Slightly soluble. SMILES: O=C(CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)O. InChi Code: InChI=1S/C14H23N3O10/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27). InChi Key: QPCDCPDFJACHGM-UHFFFAOYSA-N.