DPPE (fumarate)

DPPE is a ligand for the antiestrogen-binding site (AEBS, Ki = 55.6 nM in rat liver microsomes) and derivative of tamoxifen (Cay-11629). It is selective for the AEBS over the estrogen receptor when used at a concentration of 10 µM. DPPE is cytotoxic to S10 and MCF-7 cells (IC50s = 7.5 and 12 µM) and inhibits antigen-induced histamine release in isolated rat mast cells (IC50 = 65-85 µM). It decreases uterine size in immature oophorectomized rats in a dose-dependent manner. DPPE (4 mg/kg) protects bone marrow progenitor cells from cytotoxicity induced by doxorubicin (Cay-15007) in mice.Formal Name: N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine. CAS Number: 1185241-83-1. Synonyms: BMS-217380-01, Tesmilifene. Molecular Formula: C19H25NO . C4H4O4. Formula Weight: 399.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C=CC(O)=O)O.CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1. InChi Code: InChI=1S/C19H25NO.C4H4O4/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17,5-3(6)1-2-4(7)8/h5-13H,3-4,14-16H2,1-2H3,1-2H,(H,5,6)(H,7,8). InChi Key: ZOOMDYHTGZSGDD-UHFFFAOYSA-N.