DPP-9 Inhibitor 42

DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9, IC50 = 0.0034 µM). It is selective for DDP-9 over DPP-8, DPP-4, DPP-2, fibroblast activation protein (FAP), and prolyl endopeptidase (IC50s = 0.6, >10, >5, 10, and >10 µM, respectively). DPP-9 inhibitor 42 (10 µM) induces lactate dehydrogenase (LDH) release from THP-1 acute monocytic and HL-60 promyeloblast leukemia cells.Formal Name: tert-butyl ((7S)-3r-((2-(5R,6-difluoroisoindolin-2-yl)-2-oxoethyl)amino)adamantan-1s-yl)carbamate. Synonyms: Dipeptidyl Peptidase 9 Inhibitor 42. Molecular Formula: C25H33F2N3O3. Formula Weight: 461.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(OC(C)(C)C)N[C@](C[C@H](C1)C2)(C[C@@H]1C3)C[C@]23NCC(N4CC5=C(C=C(F)C(F)=C5)C4)=O. InChi Code: InChI=1S/C25H33F2N3O3/c1-23(2,3)33-22(32)29-25-9-15-4-16(10-25)8-24(7-15,14-25)28-11-21(31)30-12-17-5-19(26)20(27)6-18(17)13-30/h5-6,15-16,28H,4,7-14H2,1-3H3,(H,29,32)/t15-,16+,24+,25-. InChi Key: PYOHEUZJJMWWMD-NDKKOABESA-N.