DM4 (hydrate)

DM4 is a thiol-containing derivative of the tubulin polymerization inhibitor maytansine. It is cytotoxic to SK-BR-3 cells (IC50 = 3.3 nM). DM4, conjugated to a humanized CD205-targeting monoclonal antibody, is selectively cytotoxic to a variety of CD205-expressing human cancer cells (EC50s = 0.1-1.32 nM) over non-CD205-expressing cells (EC50s = 14.2-22.66 nM) and reduces tumor growth in various mouse xenograft and patient-derived (PDX) cancer models.Formal Name: N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine, hydrate. Synonyms: Maytansinoid DM 4. Molecular Formula: C38H54ClN3O10S . XH2O. Formula Weight: 780.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml. SMILES: C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)=O)C)=C(Cl)C(OC)=C4)\C)OC)(NC(O3)=O)O)C)([H])O1.O. InChi Code: InChI=1S/C38H54ClN3O10S.H2O/c1-21-12-11-13-28(49-10)38(47)20-27(50-35(46)40-38)22(2)33-37(6,52-33)29(51-34(45)23(3)41(7)30(43)14-15-36(4,5)53)19-31(44)42(8)25-17-24(16-21)18-26(48-9)32(25)39,/h11-13,17-18,22-23,27-29,33,47,53H,14-16,19-20H2,1-10H3,(H,40,46),1H2/b13-11+,21-12+,/t22-,23+,27+,28-,29+,33+,37+,38+,/m1./s1. InChi Key: UDQFYEYHHMGCNT-YFGFGYKHSA-N.