DiSC3(5)

Description: DiSC3(5) is a lipophilic cationic fluorescent probe sensitive to changes in membrane potential. 3,3'-Dipropylthiadicarbocyanine iodide accumulates in hyperpolarized cell membranes, leading to fluorescence quenching, when the membranes are depolarized, the dye is released from the cells and the fluorescence intensity is enhanced, which is used for real-time monitoring of mitochondrial membrane potential changes and membrane hyperpolarization. The maximum excitation/emission wavelength was 622/670 nm. Target: Others. Smiles: [I-].S1C=2C=CC=CC2N(C1=CC=CC=CC=3SC=4C=CC=CC4[N+]3CCC)CCC. References: Smith TC, et al. The effect of the fluorescent probe, 3,3'-dipropylthiodicarbocyanine iodide, on the membrane potential of Ehrlich ascites tumor cells. Biochem Biophys Res Commun. 1980 Jul 31,95(2):722-7.