Diphemanil (methyl sulfate)

Diphemanil is a quaternary ammonium anticholinergic agent. It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC50 = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine, Cay-14486) in vagotomized cats (ED50s = 17.5 and 19.3 µg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.Formal Name: 4-(diphenylmethylene)-1,1-dimethyl-piperidinium, methyl sulfate. CAS Number: 62-97-5. Synonyms: NSC 41725. Molecular Formula: C20H24N . CH3SO4. Formula Weight: 389.5. Purity: >98%. Formulation: (Request formulation change), A liquid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)/C3=CC=CC=C3.[O-]S(=O)(OC)=O. InChi Code: InChI=1S/C20H24N.CH4O4S/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18,1-5-6(2,3)4/h3-12H,13-16H2,1-2H3,1H3,(H,2,3,4)/q+1,/p-1. InChi Key: BREMLQBSKCSNNH-UHFFFAOYSA-M.