Diminazene (aceturate)

Diminazene is a diamidine that is cytotoxic to protozoa, including Trypanosoma, Babesia, and Cytauxzoon. Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins. Diminazene inhibits diamine oxidase with a Ki value of 13 nM. In Trypanosoma, transport proteins are important in the effectiveness of diminazene. In rats and in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2.Formal Name: N-acetyl-glycine, compd. with 4,4'-(1-triazene-1,3-diyl)bis[benzenecarboximidamide] (2:1). CAS Number: 908-54-3. Molecular Formula: C14H15N7 . 2C4H7NO3. Formula Weight: 515.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 231, 376 nm. SMILES: N=C(N)C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1.OC(CNC(C)=O)=O.OC(CNC(C)=O)=O. InChi Code: InChI=1S/C14H15N7.2C4H7NO3/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18,2*1-3(6)5-2-4(7)8/h1-8H,(H3,15,16)(H3,17,18)(H,19,20),2*2H2,1H3,(H,5,6)(H,7,8). InChi Key: OKQSSSVVBOUMNZ-UHFFFAOYSA-N.