Dihydrosanguinarine

Dihydrosanguinarine is an alkaloid and a metabolite of the alkaloid sanguinarine (Cay-16951) that has diverse biological activities. It inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells when used at concentrations of 10, 20, and 30 µM. It also reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells.Formal Name: 13,14-dihydro-13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine. CAS Number: 3606-45-9. Synonyms: DHSA. Molecular Formula: C20H15NO4. Formula Weight: 333.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. SMILES: CN1CC2=C(C=CC3=C2OCO3)C4=C1C(C=C(OCO5)C5=C6)=C6C=C4. InChi Code: InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3. InChi Key: CIUHLXZTZWTVFL-UHFFFAOYSA-N. Origin: Plant/Macleaya cordata (Willd.) R. Br..