Dihydroresveratrol

Dihydroresveratrol is a polyketide synthase-derived bibenzyl that has been found in C. sativa and has diverse biological activities. It is also an active metabolite of resveratrol (Cay-70675, Cay-10004235) that is formed by gut microbiota. Dihydroresveratrol inhibits DNA polymerase alpha but not DNA polymerase delta (Kis =29.3 and >100 µM, respectively) and the formation of thiobarbituric acid reactive substances (TBARS) in rat liver microsomes (EC50 = 1.57 µM). It stimulates the proliferation of hormone-sensitive MCF-7 breast cancer cells but not hormone-resistant MDA-MB-231 and BT474 breast cancer cells when used at concentrations ranging from 0.01 pM to 100 nM. Dihydroresveratrol decreases interalveolar septal thickness and alveolar hemorrhage in a rat model of lung injury induced by cerulein- and LPS-stimulated pancreatitis when administered at a dose of 50 mg/kg.Formal Name: 5-[2-(4-hydroxyphenyl)ethyl]-1,3-benzenediol. CAS Number: 58436-28-5. Synonyms: 3,4',5-Trihydroxybibenzyl, alpha,beta-Dihydro-3,4',5-trihydroxystilbene. Molecular Formula: C14H14O3. Formula Weight: 230.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >100 mg/ml, DMSO: >50 mg/ml, Ethanol: >50 mg/ml, PBS (pH 7.2): <100 µg/ml. lambdamax: 226, 281 nm. SMILES: OC1=CC(CCC2=CC=C(O)C=C2)=CC(O)=C1. InChi Code: InChI=1S/C14H14O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h3-9,15-17H,1-2H2. InChi Key: HITJFUSPLYBJPE-UHFFFAOYSA-N.