Dihydromyricetin

Dihydromyricetin is a natural flavanonol isolated from A. grossedentata, H. dulcis, and other plants that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties. Dihydromyricetin scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC50 = 0.235 µg/ml) and decreases reactive oxygen species (ROS) generated by AAPH (Cay-82235) in human erythrocytes when used at a concentration of 6 µg/ml. It dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells, but does not affect proliferation of normal hepatic HL7702 cells. In vivo, it decreases tumor volume by 43.5% in a HepG2 mouse xenograft model when administered at a dose of 500 mg/kg per day. Dihydromyricetin binds to GABAA receptors in rat cortical membrane reparations (IC50 = 4.36 µM) and dose-dependently reduces loss of righting reflex (LORR) in ethanol-intoxicated rats. It also improves cognitive deficits in a mouse model of Alzheimer's disease when administered at 2 mg/kg for three months.Formal Name: (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 27200-12-0. Synonyms: (+)-Dihydromyricetin. Molecular Formula: C15H12O8. Formula Weight: 320.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 208, 291 nm. SMILES: OC1=CC(O)=C(C([C@H](O)[C@@H](C2=CC(O)=C(O)C(O)=C2)O3)=O)C3=C1. InChi Code: InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1. InChi Key: KJXSIXMJHKAJOD-LSDHHAIUSA-N.