Dichlorphenamide

Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye. Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days. Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.Formal Name: 4,5-dichloro-1,3-benzenedisulfonamide. CAS Number: 120-97-8. Synonyms: Diclofenamide. Molecular Formula: C6H6Cl2N2O4S2. Formula Weight: 305.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 213 nm. SMILES: ClC1=C(S(N)(=O)=O)C=C(S(N)(=O)=O)C=C1Cl. InChi Code: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14). InChi Key: GJQPMPFPNINLKP-UHFFFAOYSA-N.