Dibutyryl-cGMP sodium

Description: Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog that preferentially activates cGMP-dependent protein kinase (PKG). It inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma thrombin and can induce peripheral analgesia by activating ATP-sensitive K+ channels. Target: Others. Smiles: [Na].[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](OC(=O)CCC)[C@@]([H])(O2)n1cnc2c1[nH]c(NC(=O)CCC)nc2=O. References: Borán MS, et al. The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes. J Neurochem. 2007 Jul,102(1):216-30.