DHEA Sulfate

Dehydroepiandrosterone (DHEA) is a C19 steroid also known as 5-androsten-3 beta-ol-17-one. DHEA and DHEAS (an active, sulfated form of DHEA), are endogenous hormones secreted by the adrenal cortex in primates and a few non-primate species in response to ACTH. DHEA is a steroid precursor of both androgens and estrogens, and thus is often called 'the mother hormone'. Endogenous DHEA is thought to be important in several endocrine processes, but current medical use of DHEA is limited to controlled clinical trials. Nomenclature: 5-Androsten-3-beta-ol-17-one sulfate, sodium salt, Melting Point: , 132.2-137.5ºC, Specific Rotation: +10.5°, Solubility: Soluble in most organic solvents. TLC Conditions: Chloroform: Methanol: Acetic acid, 21:2:2, Visualized with UV and p/TSA iodine, Single Spot: Rf=0.18. Loss on Drying: < 10%, pH: 6.0±1.0, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.