Deltorphin II (trifluoroacetate salt)

Description: Deltorphin II is a peptide agonist of delta2-opioid receptors.1,2It is selective for delta-opioid receptors over µ- and kappa-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 µM, respectively) and induces [35S]GTPgammaS binding in mouse brain membrane preparations (EC50= 0.034 µM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the delta2-opioid receptor antagonist naltriben but not the delta1-opioid receptor antagonist BNTX.3Intrathecal administration of deltorphin II (15 µg/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.4. Target: Others. References: Raynor, K., Kong, H., Chen, Y., et al.Pharmacological characterization of the cloned kappa-, delta-, and µ-opioid receptorsMol. Pharm.45(2)330-334(1994)