Deltorphin C (trifluoroacetate salt)

Deltorphin C is a peptide agonist of delta-opioid receptors (Ki = 0.15 nM) that has been found in Phyllomedusa bicolor. It is selective for delta-opioid receptors over µ- and ?-opioid receptors. It induces delta-opioid receptor translocation from large dense-core vesicles to the cell surface and induces calcitonin gene-related peptide (CGRP) release in isolated mouse dorsal root ganglion (DRG) cells when used at concentrations of 0.1 and 1 µM, respectively, effects that can be blocked with the delta-opioid receptor antagonist naltrindole (Cay-9000705). Intrathecal administration of deltorphin C (0.15, 1.5, and 15 µg/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.Formal Name: L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-L-valyl-glycinamide, trifluoroacetate salt. Synonyms: Deltorphin I, [D-Ala2]Deltorphin. Molecular Formula: C37H52N8O10 . XCF3COOH. Formula Weight: 768.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 1 mg/ml. SMILES: OC1=CC=C(C[C@H](N)C(N[C@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)C=C1.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C37H52N8O10.C2HF3O2/c1-19(2)30(36(54)40-18-28(39)47)45-37(55)31(20(3)4)44-35(53)27(17-29(48)49)43-34(52)26(16-22-9-7-6-8-10-22)42-32(50)21(5)41-33(51)25(38)15-23-11-13-24(46)14-12-23,3-2(4,5)1(6)7/h6-14,19-21,25-27,30-31,46H,15-18,38H2,1-5H3,(H2,39,47)(H,40,54)(H,41,51)(H,42,50)(H,43,52)(H,44,53)(H,45,55)(H,48,49),(H,6,7)/t21-,25+,26+,27+,30+,31+,/m1./s1. InChi Key: WVISKLVQEKTHGN-JXLAAAJESA-N. Origin: Synthetic.