(+)-delta-Tocopherol

(+)-delta-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage. It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM. (+)-delta-Tocopherol (40 µM) decreases capillary formation of HMEC-1 blood endothelial cells. It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. (+)-delta-Tocopherol (10 µM) reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells. Dietary administration of (+)-delta-tocopherol (0.2%) reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model. [Matreya, LLC. Catalog No. 1790]Formal Name: (2R)-3,4-dihydro-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol. CAS Number: 119-13-1. Synonyms: D-delta-Tocopherol. Molecular Formula: C27H46O2. Formula Weight: 402.7. Purity: >98%. Formulation: (Request formulation change), A solution in hexane. Solubility: Chloroform: Soluble, Ethanol: Soluble, Hexane: Soluble, Methanol: Soluble. SMILES: CC1=C2C(CC[C@@](C)(O2)CCC[C@@H](C)CCC[C@@H](C)CCCC(C)C)=CC(O)=C1. InChi Code: InChI=1S/C27H46O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h18-22,28H,7-17H2,1-6H3/t21-,22-,27-/m0/s1. InChi Key: GZIFEOYASATJEH-BERHBOFZSA-N. Origin: Plant/Unidentified sp..