Dehydrocorydaline (chloride)

Dehydrocorydaline is an alkaloid that has been found in C. yanhusuo and has diverse biological activities. Dehydrocorydaline inhibits serotonin (5-HT, Cay-14332) reuptake by organic cation transporter 2 (OCT2) and dopamine reuptake by OCT3 (IC50s = 0.137 and 0.354 µM, respectively, for human recombinant transporters), as well as reduces dopamine, 5-HT, and norepinephrine reuptake in mouse brain synaptosomes. In vivo, dehydrocorydaline (1.5 and 3 mg/kg) decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress. Dehydrocorydaline (10 mg/kg) reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain.Formal Name: 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-dibenzo[a,g]quinolizinium, monochloride. CAS Number: 10605-03-5. Molecular Formula: C22H24NO4 . Cl. Formula Weight: 401.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 20 mg/ml. SMILES: COC1=CC=C2C(C=[N+](CCC3=CC(OC)=C(OC)C=C34)C4=C2C)=C1OC.[Cl-]. InChi Code: InChI=1S/C22H24NO4.ClH/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23,/h6-7,10-12H,8-9H2,1-5H3,1H/q+1,/p-1. InChi Key: WXOSEFNJXIPZNV-UHFFFAOYSA-M. Origin: Plant/Corydalis yanhusuo.