Dehydroabietic Acid

Dehydroabietic acid is a diterpene acid that has been found in P. elliottii resin and has diverse biological activities. It is active against L. amazonensis promastigotes (IC50 = 40 µg/ml). Dehydroabietic acid (2.5, 5, and 10 µM) increases the number of mitochondrial ridges, decreases mitochondrial outer membrane rupture, and increases the expression of FSP1 and COQ10 in an HL7720 cell model of ferroptosis induced by oleic acid (Cay-90260, Cay-24659). In vivo, dehydroabietic acid (10 and 20 mg/kg) reduces hepatic total cholesterol and triglyceride levels, ferroptosis, and lipid peroxidation in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). Dehydroabietic acid is also found in wood industry effluents and is considered a pollutant. It increases oxygen consumption and cellular heat production and reduces cellular ATP content in isolated rainbow trout (O. mykiss) hepatocytes.Formal Name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid. CAS Number: 1740-19-8. Synonyms: (+)-Dehydroabietic Acid, NSC 2952. Molecular Formula: C20H28O2. Formula Weight: 300.4. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml. SMILES: C[C@@]12[C@](CCC3=CC(C(C)C)=CC=C32)([H])[C@@](C)(CCC1)C(O)=O. InChi Code: InChI=1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1. InChi Key: NFWKVWVWBFBAOV-MISYRCLQSA-N. Origin: Synthetic.