Deferiprone

Deferiprone is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities. It reverses ferroptosis induced by erastin (Cay-17754) in HT-1080 fibrosarcoma cells when used at a concentration of 100 µM as well as reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes at 200 and 50 µM, respectively. Deferiprone reduces cholesterol diet-induced increases in the levels of amyloid-beta (1-42) (Abeta42), Abeta40, and the phosphorylation of tau and glycogen synthase kinase-3beta (GSK-3beta) in the rabbit hippocampus when administered at a dose of 50 mg/kg. Formulations containing deferiprone have been used in the treatment of thalassemia.Formal Name: 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone. CAS Number: 30652-11-0. Synonyms: CGP 37391, DN 18001AF. Molecular Formula: C7H9NO2. Formula Weight: 139.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: MeOH:PBS (pH 7.2), (1:1): 0.5 mg/ml, Methanol: 5 mg/ml. lambdamax: 218, 283 nm. SMILES: O=C1C(O)=C(C)N(C)C=C1. InChi Code: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3. InChi Key: TZXKOCQBRNJULO-UHFFFAOYSA-N.