Decursinol

Decursinol is a coumarin that has been found in Angelica gigas and has diverse biological activities. It inhibits glutamate-induced neuronal cell death in primary rat mixed cortical cells when used at concentrations of 0.1, 1, and 10 µM. Dietary administration of decursinol (0.004%) reduces decreases in spontaneous alternation induced by amyloid-beta (1-42) (Abeta42, Cay-20574) in the Y-maze, indicating prevention of memory deficits, in mice. Decursinol (10 mg/kg) reduces tumor metastasis in a CT26 colorectal cancer mouse xenograft model. It inhibits acetic acid-induced writhing in mice when administered at a dose of 50 mg/kg.Formal Name: (7S)-7,8-dihydro-7-hydroxy-8,8-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one. CAS Number: 23458-02-8. Synonyms: (+)-Decursinol. Molecular Formula: C14H14O4. Formula Weight: 246.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 15 mg/ml, Ethanol: slightly soluble. lambdamax: 331 nm. SMILES: O[C@H]1CC2=CC(C=CC(O3)=O)=C3C=C2OC1(C)C. InChi Code: InChI=1S/C14H14O4/c1-14(2)12(15)6-9-5-8-3-4-13(16)17-10(8)7-11(9)18-14/h3-5,7,12,15H,6H2,1-2H3/t12-/m0/s1. InChi Key: BGXFQDFSVDZUIW-LBPRGKRZSA-N. Origin: Plant/Angelica sinensis.