Debio 0123 (hydrochloride)

Debio 0123 is an inhibitor of the checkpoint kinase WEE1 (IC50 = 0.8 nM). In vivo, debio 0123 (30 mg/kg per day), in combination with the inhibitor of topoisomerase II etoposide (Cay-12092), reduces tumor volume in a patient-derived xenograft (PDX) mouse model of stomach cancer.Formal Name: 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-pyrimido[4,5-d]pyrimidin-4(1H)-one, hydrochloride. Synonyms: WEE1-IN-5, WEE1 Inhibitor 5. Molecular Formula: C26H28Cl2N6O . XHCl. Formula Weight: 511.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C1C2=CN=C(NC3=CC=C(C4CCN(CC4)C)C(C)=C3)N=C2N(CN1C5=C(Cl)C=CC=C5Cl)C.Cl. InChi Code: InChI=1S/C26H28Cl2N6O.ClH/c1-16-13-18(7-8-19(16)17-9-11-32(2)12-10-17)30-26-29-14-20-24(31-26)33(3)15-34(25(20)35)23-21(27)5-4-6-22(23)28,/h4-8,13-14,17H,9-12,15H2,1-3H3,(H,29,30,31),1H. InChi Key: UDAGSHAGFNMGCH-UHFFFAOYSA-N.