Dantrolene (sodium salt)

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 µM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 µM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 µM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.Formal Name: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione, monosodium salt. CAS Number: 14663-23-1. Molecular Formula: C14H9N4O5 . Na. Formula Weight: 336.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml, DMSO: 2 mg/ml. lambdamax: 226, 309, 348, 387 nm. SMILES: O=[N+]([O-])C1=CC=C(C2=CC=C(/C=N/N3CC([N-]C3=O)=O)O2)C=C1.[Na+]. InChi Code: InChI=1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22,/h1-7H,8H2,(H,16,19,20),/q,+1/p-1/b15-7+,. InChi Key: KSRLIXGNPXAZHD-HAZZGOGXSA-M.