Danirixin

Danirixin is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2, IC50 = 12.5 µM). It is selective for CXCR2 over CXCR1 (IC50 = 977 nM). Danirixin inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52). It inhibits neutrophil surface expression of CD11b in isolated rat whole blood (IC50 = 890 nM). Danirixin reduces bronchoalveolar lavage fluid (BALF) neutrophil infiltration in rat models of LPS- or ozone-induced pulmonary neutrophilia (ED50s = 1.4 and 16 mg/kg, respectively).Formal Name: N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-urea. CAS Number: 954126-98-8. Synonyms: GSK1325756. Molecular Formula: C19H21ClFN3O4S. Formula Weight: 441.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 266, 323 nm. SMILES: FC1=CC=CC(NC(NC2=CC=C(Cl)C(S([C@H]3CCCNC3)(=O)=O)=C2O)=O)=C1C. InChi Code: InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1. InChi Key: NGYNBSHYFOFVLS-LBPRGKRZSA-N.