Daidzein

Daidzein is an isoflavone phytoestrogenic compound that has been found in soybeans and other legumes. It binds to estrogen receptor beta (ERbeta, Ki = 2.8 µM) but not ERalpha at concentrations up to 1 mM. It is estrogenic in vitro, increasing gene transcription mediated by the estrogen response element (ERE) in a reporter assay in an ERbeta-dependent manner (EC50 = 2.8 µM for MCF-7 cells expressing ERbeta). Daidzein is an inhibitor of carbonic anhydrase (CA) that is selective for carbonic CAVII and CAXII (Kis = 4.2 and 56 nM, respectively) over CAI, II, and IV (Kis = >10,000, >10,000, and 718.7 nM, respectively). It reduces tumor growth in a PC3 prostate cancer mouse orthotopic model when administered at a dose of 50 mg/kg per day and potentiates the effects of radiation therapy.Formal Name: 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 486-66-8. Molecular Formula: C15H10O4. Formula Weight: 254.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.15 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 249, 301 nm. SMILES: Oc1ccc(cc1)c1coc2cc(O)ccc2c1=O. InChi Code: InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H. InChi Key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N. Origin: Synthetic.