D-Pinitol

D-Pinitol is a cyclitol that has been found in several plants, including soybean and carob, and has diverse biological activities. It decreases NF-kappaB gene expression and induces DNA fragmentation and apoptosis in MCF-7 breast cancer cells. D-Pinitol induces endothelium- and nitric oxide-dependent vasodilation in isolated mouse mesenteric arteries. In vivo, D-pinitol (10 mg/kg, i.p.) reduces systolic blood pressure in mice. D-Pinitol (50 mg/kg) enhances creatine clearance, reduces tubulointerstitial fibrosis, and increases levels of the cytosolic antioxidant enzymes superoxide dismutase I (SOD1) and NAD(P)H:quinone oxidoreductase (NQO1) in a mouse model of cyclosporin A-induced nephropathy. It also decreases plasma glucose levels in a mouse model of diabetes induced by streptozotocin (Cay-13104).Formal Name: 3-O-methyl-D-chiro-inositol. CAS Number: 10284-63-6. Synonyms: 3-O-methyl-Chiroinositol. Molecular Formula: C7H14O6. Formula Weight: 194.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: partially soluble, PBS (pH 7.2): 5 mg/ml. SMILES: O[C@H]1[C@H](O)[C@H](O)[C@@H](OC)[C@H](O)[C@H]1O. InChi Code: InChI=1S/C7H14O6/c1-13-7-5(11)3(9)2(8)4(10)6(7)12/h2-12H,1H3/t2-,3-,4-,5-,6+,7+/m0/s1. InChi Key: DSCFFEYYQKSRSV-KLJZZCKASA-N. Origin: Plant/Ceratonia siliqua.