D-Glucose-6-phosphate (sodium salt)

D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis. It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate activity leads to glycogen storage disease type I or von Gierke's disease, a group of inherited metabolic diseases characterized by severe hypoglycemia, growth retardation, and hepatomegaly, due to accumulation of glycogen and fat in the liver. D-Glucose-6-phosphate is also the starting molecule of both glycolysis and the pentose phosphate pathways. Because cancer cells adopt glycolysis as a major source of metabolic energy production, and the pentose phosphate pathway plays a role in helping glycolytic cancer cells to meet their anabolic demands, this compound can be used to study the progression of this process.Formal Name: D-glucose-6-(dihydrogen phosphate), monosodium salt. CAS Number: 54010-71-8. Synonyms: G6P, Sodium Glucose-6-Phosphate. Molecular Formula: C6H12O9P . Na. Formula Weight: 282.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O.[Na+]. InChi Code: InChI=1S/C6H13O9P.Na/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14,/h1,3-6,8-11H,2H2,(H2,12,13,14),/q,+1/p-1/t3-,4+,5+,6+,/m0./s1. InChi Key: OBHLNVXMRZXIII-BTVCFUMJSA-M.