D-Glucosamine-6-phosphate (hydrate)

D-Glucosamine-6-phosphate (D-GlcN-6-P) is a monosaccharide intermediate of the hexosamine biosynthetic pathway. It is formed from D-fructose-6-phosphate by glucosamine-6-phosphate synthase (GlmS) in the presence of glutamine or from D-glucosamine (Cay-27055) by N-acetyl-D-glucosamine (GlcNAc) kinase. D-GlcN-6-P binds the GlmS riboswitch (Ki = 380 µM), a ribozyme located in the 5'-UTR of the gene encoding GlmS that, when bound by D-GlcN-6-P, inhibits GlmS production and decreases D-GlcN-6-P levels. It is a precursor in the biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), a substrate for protein glycosylation and a component of bacterial cell walls.Formal Name: 2-amino-2-deoxy-D-glucose-6 (dihydrogen phosphate), hydrate. Synonyms: D-GlcN-6-P. Molecular Formula: C6H14NO8P . XH2O. Formula Weight: 259.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OP(OC[C@H]([C@H]([C@@H]([C@H](C=O)N)O)O)O)(O)=O.O. InChi Code: InChI=1S/C6H14NO8P.H2O/c7-3(1-8)5(10)6(11)4(9)2-15-16(12,13)14,/h1,3-6,9-11H,2,7H2,(H2,12,13,14),1H2/t3-,4+,5+,6+,/m0./s1. InChi Key: UQENKMRQSJRGCB-BTVCFUMJSA-N.